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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Food insecurity at university campuses under the spotlight
2015-08-20

 

"Food insecurity is   becoming an increasing problem at South African universities, much to the surprise of university managers." - Dr Louise van den Bergh, senior lecturer and researcher at our department of Nutrition and Dietetics

More than 70% of early university dropouts in the country were forced to abandon their tertiary studies because of food insecurity and financial need.

This was one of the conclusions drawn during the first higher education colloquium on food insecurity. The colloquium was hosted on by the University of the Free State (UFS) on the Bloemfontein Campus on 14 August 2015, where researchers from universities across the country shared their research about food insecurity on university campuses.

In South Africa, university campuses are not usually associated with food insecurity but, over the last few years, tertiary education has become more accessible to an increasing number of first-generation students and students from low-income households.

Some of the research indicated that students from lower-income households are often lacking financially, even with bursaries. The research has also shown that students frequently have to use part of their bursary money to support their families. This results in students not having enough money to buy food, which means they will do almost anything to get food.

A study by the UFS Department of Nutrition and Dietetics found that as many as 60% of our students are food insecure, and experience hunger frequently. This study was the first of its kind in South Africa. In 2011, the UFS launched the No Student Hungry Bursary Programme to provide food bursaries to food-insecure students.

At the opening of the colloquium, Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, said by helping students with a basic commodity like food, you give them much more than food; you give them humanity and dignity.

Dr Louise van den Bergh, senior lecturer and researcher in the UFS Department of Nutrition and Dietetics, explains that the problem is considerably more complex than just providing for students financially.

Dr Van den Bergh says that funders need to reassess bursaries, keeping issues such as food insecurity in mind, and not focusing just on tuition.

Research presented at the colloquium: (PDF's van die slides)

UFS Food environment and nutritional practices

UFS Skeleton in the University closet

UKZN Achieving food security

UKZN Food security and academic performance

UKZN Hunger for knowledge

UKZN Perceptions of food insecurity complexities

UW Food acquisition struggles

 

 

 

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