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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS attracts excellent and diverse students
2015-08-20


Matshediso Mokoena and Thato Monkoe.
Photo: Thabo Kessah

When Thato Monkoe and Matshediso Mokoena sat for their final matric examinations in 2014, all they had on their minds was not just passing, but passing well. Little did they know at that time that passing well would place so much responsibility on their shoulders.

 

Both Thato and Matshediso come from rural and disadvantaged backgrounds. They are first-year students at the Qwaqwa Campus of the University of the Free State, and are the first in their respective families to study at a university.

 

Thato describes his situation as “sad and good at the same time”.

 

“It is good, because I am the first one at home to have completed my matric and to have gone on to study at a tertiary institution. At the same time, it is sad as I feel sorry for my siblings who, for various reasons, did not have similar opportunities when they opted out of school”, said Thato, a BEd student.

 

”Now my sister and brother, as well as the entire family, perceive me as the one with brains, and this makes me uncomfortable. However, I am up for the challenge to be the first one to graduate with a degree in my family”.

 

Matshediso Mokoena, a BSc student, who obtained distinctions in Mathematics, Physical Sciences, and Life Sciences last year, concurs with Thato.

 

”As much as my family is supportive, there is always pressure as they expect the best from me,” she said.

 

“The pressure does not only come from my family. My entire community looks up to me, and they can’t stop talking about my achievements”, Matshediso revealed.

 

Both Thato and Matshediso are, however, happy that the dark cloud of doubt about academic achievement in their families has finally disappeared.

 

“At least someone in my family is hard at work carving her future, and willing to set a good example. That person is me”, said Matshediso, who aspires to be a medical doctor, and has a younger sister in Grade 8.

 

Thato and Matshediso are just two of hundreds of students making good use of the University of the Free State’s commitment to attract excellent and diverse students at both undergraduate and postgraduate levels, as reflected in the Strategic Plan 2015-2020.


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