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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Rag spreads the spirit of Ubuntu in Dinaweng informal settlement
2015-08-25

 

The Rag Committee teamed up with Prowess to create the first pop-up Street Store in Bloemfontein, as part of the Ubuntu Community Store Project. On 22 August 2015, the residents of Dinaweng had the opportunity to get hold of new and second-hand clothing free of charge. Soup and bread were also served to the children and the elders of the area, which is all too familiar to the media for its high unemployment, crime, and prostitution rates.

How do clothes represent Ubuntu?

From Tubatsi Moloi’s perspective, this is the team’s way of demonstrating that Ubuntu does not exist merely as a philosophy. The Rag Committee shows compassion to communities that lack resources essential to leading a dignified life.

“Ubuntu basically means uniting with the community by giving back and also thinking for those who are in need,” says the RAG Committee Executive.

Prowess, a Non-Profit Organisation (NPO) run by Kovsie students, initiated the concept which targets homeless and needy individuals unable to purchase clothing. Students from all 26 Kovsie residences and personnel have since supported the initiative by donating to the inaugural Street Store through representatives of Rag in residences.

The Street Store will continue to empower impoverished communities within the Mangaung Metro, and champion these human projects in collaboration with external stakeholders.
“We will also be working with Twee-Toring Church, although it has not yet been confirmed when we will pay them a visit,” said Tubatsi.

Providing basic needs such as clothing has the power to reinstate the dignity of people. Rag and Prowess have taken it upon themselves to practice the ideals of Ubuntu in an attempt to ensure that the less fortunate lead dignified lives.

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