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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

‘I’d rather wake up at 8’clock for nothing than to sit at home’
2015-08-26


Tawanda Kaseke is on a mission to give back to the community one holiday at a time.

Studying towards a degree is one aspect of being a student. Investing time in worthwhile extra-mural activities forms a significant part of your student years. Tawanda Kaseke demonstrates how volunteering time to a good cause makes for a responsible student and citizen.

 

The second-year Public Administration student’s moral obligation to community development led him to spend approximately two months of his June 2015 holidays volunteering. Serving as a volunteer Admin intern at Afrika Tikkun’s ignited his aspiration to assist children from underprivileged communities to access education.

 

From cradle to career: a journey from infancy to varsity and beyond

 

Afrika Tikkun is a non-profit organisation (NGO) that works toward a future where today’s children and youth are tomorrow’s productive citizens. The NGO adopts a cradle-to-career model, which invests in the development of disadvantaged children from early infancy through young adulthood into the world of work.

 

Raising funds for the “Like Change” movement – a division of the “From Cradle to Career” project - is Tawanda’s primary objective for his November to February summer vacation.

 

Tawanda encourages social media users to contribute by clicking on the “Like” option on the ‘Like Change’ Facebook page.  A private company automatically donates R35 towards the education of an underprivileged child on your behalf.

 

Making your mark begins with a dot; university holidays are Tawanda’s dot. A passion for community development and a willingness to volunteer one’s time can go a long way in making South Africa a better place.

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