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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Afrikaans Language Day invites greater university community to celebrate the language
2015-08-26

On 14 August 2015, the Vuur en Vlam Committee hosted an event which provided the university community the opportunity to celebrate Afrikaans Language Day. The occasion celebrated the establishment of the language in South Africa. With the unexpected arrival of the Dutch in 1652, the language transition proved a struggle for the indigenous peoples domiciled on African soil.

The committee’s primary objective was to change existing cultural connotations associated with the Afrikaans language.  The use of diversity can help undermine the African stereotype held about the Afrikaans language, and thus bring about a mindset shift. It is important to remember that not all Afrikaans speakers are white, and emphasis is rarely directed to the diversity of Afrikaans speakers.

Approaching the celebration, a sensitive discussion around the Afrikaans language was hosted, in which various panel members discussed the state and current outlook of the language. Prof André Keet, Director of the Institute for Reconciliation and Social Justice, who was part of the panel said, “No language gets to be misused to maintain the privilege of the past.” Director of the Free State Arts Festival, Ricardo Peach, shared the notion that “We must build on what we have, and not break it down,” while he describes himself as a “polluted language boer”. While there is a strongly-expressed hatred for the Afrikaans language, Peach maintained further that there is much work to be done in order to “Break down the link between the language and the Holocaust which took place in the homes of Afrikaans people.”

Lindiwe Kumalo, chairperson of the Vuur en Vlam Committee, said: “We are creating an awareness around campus that Afrikaans is not dead. Once you know the language, you can interact with other people, and there is no longer that language barrier.” Amongst other things, the event encouraged dialogue by creating fun and interactive activities which exposed visitors to the language.

The Vuur en Vlam Committee is committed to creating an awareness of, and vibrancy around, the Afrikaans language, and to engaging the broader university community.

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