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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Alumni inspired to keep flying the Kovsie flag high at reunion weekend festivities
2015-09-01

Dr Khotso Mokhele and Adv Roelf Meyer

The University of the Free State hosted alumni from all over the country on the Bloemfontein Campus during a weekend of exciting events, talks, and tours around the campus on 28 and 29 August 2015.

The celebratory events were kick-started with a leadership symposium hosted by Dr Marcus Ingram, Director: Institutional Advancement with Adv Roelf Meyer. The symposium was attended by current student leaders and the SRC Presidents Alumni Association. In his dialogue with the audience, Adv Meyer shared his experiences and personal growth in the process of bringing about democracy in the country with student leaders as change agents. “If you really want to contribute to change, it is not only an intellectual exercise; it is also a heart and soul thing,” he said.

The anchor event was the inaugural Chancellor’s Distinguished Alumnus Award Luncheon hosted by Chancellor, Dr Khotso Mokhele. Prof Jonathan Jansen, Vice-Chancellor and Rector, welcomed guests by highlighting the latest extraordinary achievements of UFS students and academic staff.

Keynote speaker of the day, Ms Nozizwe Madlala-Routledge, Executive Director of Inyathelo and a renowned politician, spoke of the role that universities have in preparing women for leadership roles and how they, in turn, can prepare society for female leadership.  She commended the UFS’s advancement efforts supported by the Kresge Foundation, which supports young people, to keep them in universities. “I am proud to say that the UFS’s efforts in advancement have achieved its goals.”

In his remarks, Dr Mokhele said “what draws a student back to his/her Alma Mater is the quality of the experience they had on campus.  This campus contributed to the transformation of this country through alumni such as Roelf Meyer and Kobie Coetsee.”  He said this initiative should create a lived experience for students on the university campus.  The Chancellor presented the Distinguished Alumnus Award to Adv Roelf Meyer, for his outstanding contributions to the human interests of South Africa, and his current work of facilitating peace processes around the world.

In accepting the award, Adv Meyer introduced Youth Zones, a project which he has been involved with for the past five years, empowering and supporting 40,000 youths in the Free State. In accepting the award, he said “I was a first-year student in 1960, my year group represented the most emphatic group of this university. There are many who came before and after us who well deserve this award, therefore, I accept it on behalf of all alumni.”

To wrap up the weekend’s festivities, former SRC President, Richard Chemaly, hosted the Faculty of Law alumni cocktail event at the CR Swart Auditorium.
Speaking at the event, Prof Caroline Nicholson, Dean of the Faculty of Law, said “A faculty cannot exist without its alumni, we need you to carry us.  Your continued support and collaboration is truly appreciated.”

Alumni and staff enjoyed further entertainment by well-known musical groups, Freshly-Ground and The Muses.

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