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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Mandela statues and the issue of public representation
2015-09-04

   

Prof Grant Parker, Associate Professor of Classics and Co-Director of the Centre for African Studies at Stanford University, USA, presented a public lecture on the Bloemfontein Campus on 27 August 2015, in which he explored the topic of ”Memorialising Mandela after Rhodes Must Fall”. What stories do the multitude of Mandela statues tell us about the man? Our society? Ourselves? These were some of the questions Prof Parker addressed during his lecture.

Paradoxes
Prof Parker discussed some of the paradoxes presented by the Mandela statues. The huge 9m high Mandela statue at the Union Buildings in Pretoria does not necessarily reflect his humility. Iconic statues strewn across the world do not reveal Madiba’s appeal. “Madiba’s charm,” Prof Parker said, “was all about his ability to relate to people of very different backgrounds. People who were his enemies would – to their surprise – find a humanity they were not expecting. It’s very hard to reconcile that with the colossal statues.”

Rhodes Must Fall
On the topic of the Rhodes Must Fall campaign, Prof Parker said that “the debates around it seem to express the frustration of deepening equality in general and lack of demographic change.” He also believes that, although the campaign centres on statues, there are much deeper issues at play that need to be addressed.

Artists should be part of the conversation
Prof Parker also advocated that artists’ voices should be incorporated into the creative processes of public art. “There is a much greater need for creative artists,” he concluded, “to be part of conversations, not only about what we as South Africans want to commemorate, but how we do that. I would very strongly suggest that this be done by non-figural representations.”

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