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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Student Court is ready to exercise its legal power

2015-09-07

Student disputes at the University of the Free State (UFS) will be regulated henceforth by the Student Court that has been re-established at the Bloemfontein Campus. The Student Court will offer practical training to law students thus strengthening their theoretical knowledge to produce employable graduates.

The Student Court was launched on Friday 21 August 2015, cultivating a self-determined studentship and citizenship, of which South Africa can be proud.

Advocate Barry Roux, Oscar Pistorius’s defence attorney, Judge Lebotsang Bosielo, of the South African Supreme Court of Appeal, Profs Caroline Nicholson, Dean of the Faculty of Law, and Teuns Verschoor, Chairperson of the UFS Disciplinary Board, attended this auspicious event.

During his keynote address, Adv. Roux said the Student Court serves as a stepping-stone in the practice of integrity, respect, and preparedness within the law profession.

“Young professionals have a mandate to excel. No matter what, stick to honesty and the truth. If you want to be a role model and make your family proud, do more.” he advised.

Judge Lebotsang Bosielo urged students to use “the rare opportunity to practise and uphold the law with austerity.”

“You should broaden the knowledge of substantive law, law of evidence, procedural law, and the Constitution of South Africa. Opportunities such as the Student Court enable law students to strengthen the practice of theory beyond the parameters of the lecture rooms,” he emphasised.

The re-establishment of the Student Court was initiated by Lindokuhle Ntuli, Student Representative Council (SRC) member on Legal and Constitutional Affairs. The UFS Council approved the proposal for the court in 2006, but it had remained inactive since then. It was not until 2014 when Lindokuhle assumed office that the concept was revived.

“As an independent body, the Student Court is ready to exercise its legal powers with the aim of establishing a student community and a culture of student governance committed to justice, equality, and accountability,” he said.

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