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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Two research chairs awarded to UFS women

2015-09-15

Prof Pumla Gobodo-Madikizela

Two professors at the University of the Free State (UFS) have just been chosen as recipients of research chairs by the National Research Foundation’s South African Research Chair Initiative.

The research chairs are a massive financial injection for research in each of the relevant disciplines – that of Profs Pumla Gobodo-Madikizela from the Centre for Trauma, Forgiveness, and Reconciliation Studies at the UFS, and Felicity Burt from the Department of Medical Microbiology in the Faculty of Health Sciences.

Profs Gobodo-Madikizela and Burt are two of 42 female researchers in the country receiving research chairs as an initiative to give due recognition to women in research.

Profs Hendrik Swart, from our Departement of Physics and Melany Walker, Director, Centre for Research on Higher Education and Development, each also holds research chairs by the NRF. A third research chair has also been granted to the UFS Department of Plant Sciences for the research in field crops.

Prof Felicity Burt

The work of Prof Burt’s research chair is to investigate medically significant vector-borne and zoonotic viruses currently circulating; to define associations between these viruses and specific disease manifestations that have previously not been described in our region, to increase awareness of these pathogens; to further our understanding of host immune responses, which should facilitate development of novel treatments or vaccines and drug discovery.

Prof Gobodo-Madikizela, who has received international recognition for her work on forgiveness studies, will use this research chair to investigate historical trauma within two African contexts – those of South Africa and Rwanda. She hopes to gain insight into the role that memory plays in the formation of the experience of trauma, and to bring about healing of the trauma.

Prof Corli Witthuhn, Vice-Rector: Research at the UFS, expressed her pride on the announcement.

“We are extremely proud of the national recognition these two outstanding women researchers received. The UFS strives for research excellence, and the five current NRF research chairs, as well as two NRF A-graded researchers who are at the forefront of their disciplines globally, indicates our continued commitment to innovating, relevant, and high-impact research. We are excited about the progress of the past two years to position the UFS as a national leader in research.”

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