Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Walking and running routes launched on UFS Bloemfontein Campus
2015-09-16

Photo: Hatsu Mphatsoe

On Casual Day, Friday 4 September 2015, the UFS Health and Wellness Centre and KovsieSport launched a healthy lifestyle on the Bloemfontein Campus with the focus on Walking and Running routes. The theme of the event was set by the many flying tutus, together with outrageous outfits that were to be seen in the crowd of anxious and excited runners.

There are a total of six walking and jogging routes, stretching over the central and western parts of the Bloemfontein Campus. Colour-coded arrows indicate the various routes, ranging from a three-kilometre route (green) to an eight-kilometre route (black). The 2,5 km route is accessible for people with wheelchairs.
 
According to Arina Engelbrecht, who is spearheading the Wellness programme, a board will be erected in front of the Callie Human Centre later on, explaining the various routes. All the routes start and finish at the Callie Human Centre.

This initiative is receiving support from management, who requested that a healthy lifestyle be encouraged amongst students and staff. With this project, staff and students can train and exercise in a safe environment. The routes are also wheelchair friendly, and will be expanded to cycle routes in the future.

Various departments showed their support in numbers, bringing together teams that competed. Staff and students were excited to see what bends and turns lay ahead of them on the trails. Prof Nicky Morgan: Vice-Rector: Operations, cut the ribbon at the official opening of the routes. Morgan himself was extremely excited about the event, as he navigated his way energetically between the runners and walkers.

In his opening speech, Pieter du Plessis, Executive Assistant to the Vice-Rector: Operations, talked about the importance of keeping healthy by doing something as simple as walking, an inexpensive method of keeping healthy.

Arina commented: “We received some great feedback from the masses that attended, and many said they will continue to make use of the routes.”
 
This event forms part of the human project of the UFS, and will also create awareness amongst staff and students about persons with disabilities.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept