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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Odeion School of Music launches new Organ Chair
2015-09-16



Liesbeth Schlumberger-Kurpershoek

The Odeion School of Music (OSM) at the University of the Free State (UFS) has become the first in the country to launch an Organ Chair, named after seasoned international organist Liesbeth Schlumberger-Kurpershoek.

Over the last two decades South African has seen a decline in organ student numbers. The School of Music has taken the initiative by deploying experts and instructors to coach and mentor OSM students, in an effort to increase their chances of excelling in the international music scene.

The Organ Chair is an entity of the International Artistic Mentorship Programme (IAMP), which aims to establish partnerships between successful international musicians and OSM students. It is within this context that the OSM decided to launch the institutionalisation of an Organ Chair in a programme scheduled to take place from 8 -13 September 2015 in the Bloemfontein Campus and in surrounding areas.

Meet the expert

Liesbeth Schlumberger-Kurpershoek is a French-South African organist and pedagogue, who is well versed in the music profession. This bodes well for our university’s music students.  Initially educated by the great Stephanus Zondagh at the University of Pretoria while still a school pupil, Liesbeth’s passion for music has soared to great height since then.

Some of her accolades include winning the prestigious SABC Music Prize in 1985, and the International Organ Competition held in Bordeaux in 1989.

Liesbeth has worked with distinguished organists at the France Conservatoire National de Ruiel-Malmaison, the Conservatoire National de Région, Conservatoire National Supérieur de Musique in Lyon, and is the organist at Reformed Church of Etoile in Paris. In 2010, she was an adjudicator at the Chartres International Organ Competition, one of the most prestigious of its kind in the organ world.

This active recitalist and masterclass pedagogue facilitated classes attended by master students from Cape Town, Stellenbosch, and Potchestroom, and workshops as part of launching the Liesbeth Schlumberger-Kurpershoek OSM Organ Chair.

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