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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

DiMTEC and insurance industry join forces to address the vulnerability of communal and commercial farmers
2015-09-18

At the workshop on index-based insurance for the
agricultural sector were, from the left:
Dr Andries Jordaan, Johan van den Bergh,
Bertus Kruger and Henk Vermeulen.

The United Nations identified climate resilience as a major focus for future development to ensure a safer world for all. Tailor-made insurance and financial products ought to address the needs of the most vulnerable.

Recent research done by the Disaster Management Training and Education Centre for Africa (DiMTEC) at the University of the Free State on the vulnerability of communal and commercial farmers to external shocks highlighted the importance of insurance as an important disaster risk transfer tool. Insurance is generally unavailable to most vulnerable groups, such as communal farmers, small-holding farmers, and new commercial farmers.

For these reasons, DiMTEC invited the insurance industry and other experts to a workshop with the purpose of investigating the development of risk transfer products, especially for drought. They were the hosts of a workshop entitled “Global Resilience through Insurance and Index-Based Risk Transfer Products (IBRTP)”.

Bertus Kruger from Agriseker and Johan van der Berg from SANTAM, together with other experts, attended the workshop facilitated by Dr Andries Jordaan, Head of DiMTEC.

The group attending the workshop, agreed on the following:

- Establishing a UFS-DiMTEC-led research team to investigate the feasibility of index insurance products.
- Mobilising government support to develop risk transfer products for the most vulnerable.
- Initiating forum discussions on risk transfer products.
- Promoting collaboration between the private sector, government, and research institutions with the focus on resilience-building through financial and insurance products.

 

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