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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Deaf Awareness Month empowers the hearing impaired

2015-09-21

There are more sign languages in the world than spoken languages. About 600 000 deaf South Africans have the South African Sign Language (SASL) as their first language. There are about 40 schools for the deaf in South Africa. 90% of all deaf children are born to hearing parents. Only about 30% of speech is visible on the lips.

How many of these fundamental facts did you know?

Deaf Awareness Month serves to educate hearing communities about issues that the deaf population face on a daily basis, as well as to honour the history and culture of people who are deaf or hard-of-hearing. For the past 70 years, the University of the Free State (UFS) has dedicated September to hosting events around the topic of hearing impairment.

The theme of ‘With South African Sign Language rights, our children can!’

This year’s theme had learners from Bartimea School for the Deaf and Blind, hearing impaired UFS students, and Prof Jonathan Jansen engaged in a conversation around empowerment at a picnic held on Monday 7 September 2015 at the Red Square on the Bloemfontein Campus.

Through a sign language interpreter, Matshela, a grade 12 learner, explained that he felt empowered by the efforts the university has made to embrace and empower individuals with disabilities. He then revealed his intentions of pursuing Information Technology or Social Work studies at Kovsies.

Clifford Machete, a first-year Administration student at the university, stated how sign language interpreters gave him an ‘I can’ attitude when he first arrived at university. “As a deaf person, I see that I am able to learn with the help of sign language interpreters. There is accessibility at the university, and I am so proud to be a student here and part of Deaf Awareness Month.”

Susan Lombaard, Lecturer and Acting Chairperson at the Department of South African Sign Language, believes that Deaf Awareness Month is about promoting human dignity.

“We want to show the world that deaf people can do everything, and that their language is as strong and important as any spoken language.”

For more information regarding Deaf Awareness Month activities, contact the South African Sign Language Department on 051 401 2251.

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