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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

NSH breaking the cycle of poverty

2015-09-28

In was a joyous occasion for the Hlomuka family when their last-born walked across the stage to receive her degree. Spontaneous ululating sounded from the crowd as Nozipo Hlomuka knelt before the Chancellor of the University of the Free State (UFS), Dr Khotso Mokhele, who conferred her degree.

“At that moment, I thought ‘this is really and finally happening’,” says the young teacher from Qwaqwa, who received a B Ed degree at the spring graduation.

At that moment time stood still for Nozipo, who once believed that, because of financial difficulties, this day would never come.

Across our three campuses, there are many students in similar positions to Nozipo. As many as 60% of students on our campuses are food-insecure, and suffer from hunger. The No Student Hungry Bursary Programme as established in 2011 to provide food-insecure students with a modest food bursary.

In 2014, just when Nozipo thought she could no longer continue studying, she became the recipient of an NSH-bursary.

Although receiving a degree is a huge achievement for Nozipo, her parents, too, were overcome with emotion, to see the first of their five daughters reach this academic milestone. Having only finished grade 8, Mrs Notula Hlomuka, Nozipo’s mother, says it was important for her to see her children finish school, at least. Mrs Hlomuka sold fruit and vegetables which provided the family’s only income.

“It was not always easy. It was never easy. Sometimes, there was no money and not enough to eat, and your children must go to school hungry. We could not afford new clothes for all the children, and the school uniforms were handed down to the younger sibling ending with Nozipo. Those were difficult days. It’s over now. God provided.”

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