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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Future economic development lies in humankind’s ability to learn from nature
2015-09-30

We as humans have become more powerful than we are wise. We live in a world where there is an abundance of knowledge but less wisdom. ”These were the opening remarks of Edward Kieswetter, Group CEO at Alexander Forbes, and former Chairperson of the UFS Council, as guest speaker at the UFS Business School on 23 September 2015, on the subject of the future economic world order, and the vast amount of knowledge that humans possess. “The knowledge we possess has the potential either to develop us greatly, or put us at high risk of extinction,” he said.

Mr Kieswetter was accompanied by Dr Idriss Aberkane, a French thinker, entrepreneur, and academic, who is co-founder and CEO of Scanderia Ltd. Dr Aberkane spoke of three new concepts that the world is moving towards: Knowledge Economy, Biomimicry, and the Blue Economy.  He said “humankind’s second renaissance is based on the knowledge economy.”  He added that knowledge is infinite and prolific, with its global quantity doubling every 7 to 9 years. He added that “the combination of forms of knowledge grows exponentially and non-linearly.”

On the subject of Biomimicry, he said “nature is high-tech, we should read it rather than burn it.” High-tech companies, such as Samsung and Apple Inc are beginning to use Biomimicry to produce the most advanced technological gadgets, and even more companies are using the same, to advance the fields of medicine, agriculture, production of apparel, and sustainable development.

The session was attended by MBA students, student leaders, and members of the university community.

The guest speaker series forms part of the MBA programme held at the UFS Business School throughout the year.

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