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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Ivory Coast too dependent on UN to combat violence against women

2015-10-08

During the seminar presented by the Centre for
African Studies (CAS) at the University of the Free State
were, from the left: Thesipo Machabaphala, student in
Gender Studies; Prof Heidi Hudson, Head of CAS;
Dr Peace Medie from the University of Ghana,
guest speaker; and Sesi Mahlobogoane, student in
Gender Studies.

The Ivory Coast is still too dependent on the work of the United Nations (UN) to combat violence against women in the country. There is much talk about ways to address the problem, but the government is still not acting quickly and effectively enough to make a difference in the long term.

These were some of the findings by Dr Peace Medie from the University of Ghana, guest speaker during a seminar series held by the Centre for Africa Studies (CAS) on the Bloemfontein Campus of the University of the Free State on 1 October 2015.

Dr Medie presented a seminar for students in the Gender Studies programme entitled Women, Security, and Justice: a Study of the Ivorian State’s Response to Violence against Women. Prof Heidi Hudson, Head of CAS in the Faculty of the Humanities at the UFS, facilitated the seminar.

For the sake of internationalisation, the CAS often presents guest speakers from outside South Africa to address its students. In addition , Dr Medie is from Africa.

According to Dr Medie, who conducted some 150 interviews during her research over two years, there was a shortage of resources in the Ivory Coast. This is also the case in several other African countries previously involved in war.

She believes the Ivory Coast should do more to combat violence against women successfully.

She said the UN had a great influence on the way people, especially the police, were thinking about the problem - which included sexual violence against women.

“The UN will not be there forever,” Dr Medie said.

“If response depended only on the influence of an international organisation, what would happen when the UN leaves?”

According to Dr Medie, a shortage of active women’s organisations also had a role to play. She was of the opinion that these organisations should put more pressure on the government to ensure better treatment for women.

“Local organisations are needed because it is not sustainable to depend only on the work of the UN.”

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