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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

SAFOS seeks to integrate folklore studies into education
2015-10-15

From the left are: Bahedile Letlala, Dr Elias Malete, Hannetjie du Toit, Dr Sara Motsei, Dr Edwin Mohatlane and Prof Mogomme Masoga.

The University of the Free State was proud to host the national conference of the Southern African Folklore Society which took place on 7-9 October 2015 on the Bloemfontein Campus. The focus of the conference was on how to integrate folklore studies into the 21st century.

Keynote speakers for the conference included Prof Antoinette Tidjani-Alou (Professor of French and Comparative Literature at University Abdou Moumouni), Prof Mogomme Alpheus Masoga (University of Venda), and Prof Mohlomi Moleleki (University of the Free State).

The speakers approached their subjects in great detail, tackling issues surrounding identity, social cohesion, and orality on the African context. One of the main co-ordinators of this event, Dr Elias Malete from the Department of African Languages at the UFS, highlighted one of the speaker’s topics, which focused on the importance of harnessing a collectivistic culture, as the African context does not entertain individualism. When asked about how such a conference fits into the UFS context, and where it could be applied, Malete mentioned the burning issue of the language policy review. He believes that: “The language should be inclusive, in as much as our theme says we cannot entertain individualistic approaches, but need to include everybody.” This is achieved through working with the Language Departments,” he said.

In particular, the topic presented by Prof Moleleki from the Department of African Languages, explored how the self-perception of an African, both as an integral member of his society as well as an independent individual, not only informs but also underpins his identity.

In all the topic discussed, the importance of coherence, transparency, and correctness was noted.

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