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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Campus-wide poll to determine preferences among current staff and students for language models
2015-10-20

Language poll postponed until Thursday 22 October 2015

Due to the closing down of all UFS campuses on Wednesday 21 October 2015, the language poll has been postponed until Thursday 22 October 2015.

 

Invitation to take part in a campus-wide poll to determine preferences among current staff and students for language models.

As mandated by the Council on 5 June 2015, the senior leadership of the University of the Free State (UFS) has committed itself to a formal review process of the current language policy through a comprehensive process of consultation with all university stakeholders.

Since 19 August 2015, the following public sessions have taken place across all three campuses:

  • Public dialogue for staff and students, Qwaqwa Campus, 19 August 2015
  • Staff submissions, Bloemfontein Campus, 20 August 2015
  • External stakeholder submissions, Bloemfontein Campus, 24 August 2015
  • Public dialogue for staff and students, South Campus, 26 August 2015
  • Alumni submissions, Bloemfontein Campus, 27 August 2015
  • Expert panel discussion for staff and students with Q&A, Bloemfontein Campus, 31 August 2015
  • Staff, students, and external stakeholder submissions, Qwaqwa Campus, 9 September 2015
  • Panel discussion and public dialogue for students, Bloemfontein Campus, 10 September 2015
  • Expert panel discussion for staff and students with Q&A, Bloemfontein Campus, 11 September 2015
  • Student submissions, Bloemfontein Campus, 15 September 2015
  • Staff and student submissions, South Campus, 16 September 2015
  • Convocation submissions, Bloemfontein Campus, 30 September 2015

Further, written and online submissions from the entire university community were put forward until 18 September 2015, while the Convocation had until 30 September 2015 to submit. During the process, the Language Committee has met weekly and discussed the viability, benefits and challenges of various language model options, taking into account institutional, regional, national and global concerns, documents and information.

Following the university’s commitment to open, democratic practice, the UFS calls upon all its current staff and students to participate in a campus-wide poll in order to assist the Language Committee in determining possible preferences among current staff and students for language models. The possible models have emerged from the broad consultation process.

Please note that the campus-wide poll is NOT a formal voting process or referendum and will form only one part of many deciding factors that will be referred to the UFS Council on 20 November 2015 for their deliberations regarding the future of the language policy at the UFS. The poll, conducted by the Independent Electoral Commission (IEC), will be indicative of the preferences of staff and students for possible language model options, with specific focus on language of instruction. 

The poll will take place at the following venues from 21-28 October 2015, 08:00-16:30, including the weekend:

Bloemfontein Campus: Kestell Residence Gazellie

Qwaqwa Campus: VIP Lounge

South Campus: Conference Hall

To take part in the polling, a valid staff or student card must be produced. Polling will take place on the basis of one poll per current staff member/student.

We look forward to your participation in the poll and hereby thank the entire university community for their ongoing interest and responsible engagement with the review process.

 The UFS Language Committee

 

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