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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Student gives hope to childhood cancer patients
2015-10-16


Siphokuhle Jama believes that the underprivileged are also destined to reign.

The inaugural ‘Dance and Musical Childhood Cancer Fundraising Day’, held on Saturday 26 September 2015 at the Free State Childhood Cancer (CHOC) Foundation, was “a huge success,” according to Siphokuhle Jama, the organiser.

Siphokuhle is a second-year BSc Agricultural Economics student at the University of the Free State (UFS), who has devoted his life to bettering the lives of the less fortunate. The 21-year-old self-proclaimed motivational speaker, entrepreneur, and budding author was inspired by his humble beginnings to found the Destined to Reign Foundation, which champions various community initiatives in both his home town of Mtata and Bloemfontein.

To support the fight against childhood cancer, the young philanthropist took it upon himself to invite music and dance fanatics either to perform or to enjoy spectatorship for a good cause. The impressive support received from the UFS, Universitas Academic Hospital, and Central University of Technology (CUT), various artists, and the community has contributed towards ensuring that the inaugural fundraiser was a prelude to annual events to come.

Singers, dancers, and poets entertained the audience with vigour, making the day one of the most special for the young children, who spend their days and nights at the CHOC House, with little to do but undergo radiation and chemotherapy and await a discharge date. .

All proceeds went towards basic needs, such as food, toiletries, and clothing for the children residing at the House, which is located in the same suburb as our university. In addition to accommodating dozens of cancer patients and their mothers, the House also assists with the treatment and rehabilitation of children suffering from life-threatening blood disorders. Thus, the fundraiser served to promote awareness of these health conditions.

Siphokuhle’s passion for giving hope to the underprivileged was unveiled by a school community engagement project 14 years ago. He has never looked back.“It has always been in my heart to serve my community,” he said.

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