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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Juan Odendaal invited to training camp in Switzerland
2015-10-19

Juan Odendaal recently in action at the UCI Paralympic World Cup
for road races in Pietermaritzburg.
Photo: Bertus Odendaal

Juan Odendaal from the University of the Free State (UFS) was invited to be part of a training camp in Switzerland, together with some of the world’s leading para-cyclists.

This first-year BA student was recently selected by the cycling body, Union Cyclist International (UCI), to attend the camp which will be held in Aigle from 2-12 November 2015.

Afterwards, Odendaal, who has been the junior South African champion in the C3 division in road races, time trials, and pursuit races, will travel to Manchester, England, where he will compete in a para-cycling event from 13-15 November 2015.

Recently, he took part in the senior division of the UCI Paralympic World Cup for road races for the first time, and has performed well. In this event, which was held in Pietermaritzburg, he competed against participants from countries including Germany, Australia, Spain, and Russia.

Odendaal on 11 September 2015 took eighth place in the road race and tenth place in the time trial. The road race takes place over 55 km and the time trial over 24 km.

Odendaal said he realised immediately that he was competing at senior level.

“There was a marked difference in the quality of the races,” he said, about the World Cup in Pietermaritzburg.

“It was much faster than I had expected. The average speed was 37,2 kilometres per hour.”

Odendaal also made his debut for South Africa in March of this year at the UCI Para-cycling Track World Championships in Apeldoorn, The Netherlands. At this event, he finished in fifteenth place in both the time trials and the pursuit event.

Odendaal said his main goal is the World Championships, which will take place in Montichiari, Italiy, in March 2016. He is hoping to achieve good times there in order to qualify for the 2016 Olympics in Rio de Janeiro.

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