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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Professor awarded by Cardiff University for exceptional teaching and research record
2015-10-20

Prof Pieter Duvenage
Cardiff University is one of the best research universities in the United Kingdom (UK) and the world. In 2014, Cardiff was ranked number 2 and 5 among UK universities in the Research Excellence Framework for impact and quality, respectively.

Annually, Cardiff selects and recruits the most outstanding teachers and researchers from across the globe. This year, this institution bestowed on Professor Pieter Duvenage the title of Honorary Professorship in Political Philosophy for his contribution and commitment to philosophical research in South Africa and internationally. Prof Duvenage is Head of the Department of Philosophy at the University of the Free State (UFS).

Prof Duvenage has authored and co-authored four books, publishing almost 40 accredited articles in journals and books. As a distinguished scholar, he displays immense dedication to the investigation of the political implications of intellectual traditions.

Since 1997, Prof Duvenage has been lecturing philosophy as an associate professor, full professor, or visiting professor at various South African and Australian universities. He was appointed as Head of the Department of Philosophy in 2011, where he continues to explore his interests in Phenomenology, Critical Theory, and South African Intellectual History.

His rich academic history had earned him the prestigious five-year Honorary Professorship at Cardiff’s Department of Politics.  In 2014, the same university invited Prof Duvenage to be a Professorial Fellow of the Collingwood and British Idealism Centre for an indefinite period.

Professor David Boucher, Director of the Collingwood and British Idealism Centre, has played a crucial role in initiating both processes. According to Prof Duvenage, “Professor Boucher is a respected British academic and a Distinguished Visiting Professor at the University of Johannesburg.”

When Boucher announced the good news, Prof Duvenage was very surprised. “The appointment came as a total surprise. I never studied there [at Cardiff University], therefore it was purely through academic networks.”

Considering Cardiff’s reputation and Prof Duvenage’s exceptional skill sets and values, his relationship with the world-leading university in research is bound to blossom.

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