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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Wayde, Karla crowned as KovsieSport’s best
2015-10-21

 

The pride of KovsieSport. From the left, are: Ox Nche
(UFS Junior Sportman of the Year), Karla Mostert
(Senior Sportswoman of the Year), Wayde van Niekerk
(Senior Sportsman of the Year), and Brett Walraven
(on behalf of his sister, Nicole Walraven – Junior Sportswoman of the Year).
Photo: Hannes Naude

The journey does not belong to him alone, but to everyone at KovsieSport.

These were the words of University of the Free State’s (UFS) Wayde van Niekerk, after being named as KovsieSport’s Senior Sportsman of the Year on Wednesday 21 October 2015.

The South African sports star walked away with the award for the third consecutive year, while the Protea netball defender, Karla Mostert, was crowned Senior Sportswoman for the first time.

The Junior Bok, Ox Nche, and the Protea hockey player, Nicole Walraven, were named as Junior Sportsman and Junior Sportswoman of the Year respectively.

Nche represented South Africa’s U20 rugby team this year at the Junior World Championships, played for the Shimlas, and was named the UFS Rugby Club’s best junior player.

Walraven made her debut for South Africa in 2015. She was crowned jointly as the best player at the Provincial U21 tournament, and was also Hockey South Africa’s U21 Player of the Year.

Van Niekerk won gold in the 400 metres at the World Championships in Beijing, becoming only the fourth athlete in history to run the 400 m in less than 44 seconds, and the 200 metres in less than 20 seconds.

“This is precious, and something I will cherish as an athlete: being part of KovsieSport,” he said.

“I arrived at the UFS as a high school boy, started as a junior, and was accepted immediately.”

“I really appreciate everybody who played such a huge part in my life.”

Mostert was named as Player of the Series in the Brutal Fruit series, as well as the Varsity series this year. She was also a star for the Proteas at the World Cup.

“This (the award) is definitely a good way to end my time at Kovsies. This is something one is trying to achieve for years, so it really is a highlight.”

She said it was difficult to describe how much KovsieSport is doing for its athletes, and this was the reason why the UFS achieves so many successes in sport.


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