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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Vermeulen’s work on display at Johannes Stegmann Art Gallery
2015-10-26

 

Dot Vermeulen, Anthropology (2014),
Oil on plywood, 300 x 200cm.
Photo: Supplied

“I am primarily fascinated in the travelling or movement of images in different spaces and media. By moving images from one medium into another, or posting and reposting them in different urban and virtual spaces, I ask questions about media presence and space.”

According to the late artist Dot Vermeulen, this is what the work for her Master’s degree was about. She was still completing it at the Department of Fine Arts at the University of the Free State (UFS).

Her work, called Posting Presence, is currently on display at the Johannes Stegmann Art Gallery on the Bloemfontein Campus. The exhibition is running from 1-30 October 2015.

Vermeulen was a junior lecturer at the Department of Fine Arts before she passed away in a car accident in April 2015.

According to Angela de Jesus, curator of the UFS Art Galery, the exhibition would have been part of Vermeulen’s final evaluation for her Master’s degree. She was one of South Africa’s most promising young artists, and won the prestigious Sasol New Signatures art competition in 2013.

In the work she had done in Posting Presence, Vermeulen said the spaces represented were derived from areas under bridges in an urban space where the visual messages left, speak of an accumulation of movement.

Exhibition event

An exhibition event was held on Friday 16 October 2015 at the Johannes Stegmann Art Gallery to celebrate Vermeulen’s work.

Janine Allen-Spies
and Prof Suzanne Human, the supervisors of her Master’s degree,spoke about the work to those attending.

Catalogue


De Jesus said a catalogue of Vermeulen’s research for Posting Presence had also been compiled, and would be available at the UFS Sasol Library in order for others to “use her work for further research”.

•    Vermeulen’s work can be seen from 08:30-16:30 daily until 30 October at the Johannes Stegmann Art Gallery on the Bloemfontein Campus.

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