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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

NBC tells Wayde’s story

2015-11-02

The film crew from NBC Olympics
filming Wayde van Niekerk (centre, in grey clothes)
during a practice session at Pellies Park on the
Bloemfontein Campus of the UFS.
On the left is Ans Botha, Van Niekerk’s coach.
Photo: Charl Devenish

The Kovsie star Wayde van Niekerk stands an excellent chance of shining at the 2016 Olympics and has a remarkable story behind his success.

This is why NBC Olympics, a division of the American broadcasting network NBC, selected the athlete from the University of the Free State (UFS) to do a special insert for the Olympics in Rio de Janeiro.

A film crew from NBC visited the City of Roses and the Bloemfontein Campus of the UFS on Monday 26 and Tuesday 27 October 2015 to film the insert. The feature will be screened on NBC Olympics’ platforms during and leading up to the Olympics next year.

One of four stars

Van Niekerk was one of four athletes used by the crew to film inserts on. The others were the South African swimmer Chad le Clos, the Kenyan 800 m athlete David Rudisha, and Ethiopian middle- and long-distance athlete Genzebe Dibaba.

The crew interviewed Van Niekerk and his coach Ans Botha, and also paid a visit to Pellies Park during one of his training sessions.

According to Tom Davidson, feature producer at NBC Olympics, the piece about Van Niekerk will be about three minutes long.

“We do a pretty good job of picking good stories, but it is up to the athletes to get there,” Davidson said.

“We think Wayde has a good shot at being in the finals of the 400 m at the Olympics.”

Van Niekerk won a gold medal in a time of 43.48 s at the World Championships in Beijing during August 2015 and set a new South African record for a third time and a new African record for a second time this year in the process.

Beijing success propels Wayde onto NBC radar

“Wayde’s performance in Beijing certainly propelled him onto our radar,” said Davidson.

“He beat former World and Olympic champions like Kirani James and LaShawn Merritt.”

He feels that Van Niekerk is also very young and still at university.

And Botha makes his story even more interesting.

“It is not every day that you see a 74-year old great-grandmother coaching a world champion.”

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