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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Department of Education prescribes student’s novel to schools
2015-11-03


Ntshala Mahasa: The young storyteller

Three years ago Ntshala Mahase was an ordinary high school learner studying texts prescribed by the Department of Education. Now, other learners will be reading his brainchild, Life out of the Ordinary.

The third-year LLB student at the University of the Free State (UFS) officially launched his debut novel in July 2015 at the Bloemfontein Campus. Three months later, the work of fiction has reached a milestone of note. The novel has been selected as one of 12 books from young and emerging writers to form part of the Library and Information Association of South Africa’s (LIASA) Young Writers Programme.

LIASA is the regulatory body for South African public, school, and university libraries. Ntshala’s literary contribution is to be distributed to different school libraries, as per decision of the Western Cape and Gauteng Departments of Education.

About the book

The book narrates the transformational journey of a privileged suburban school boy who one day coincidently exposes himself to the harsh realities of an impoverished South African community. Tom then decides to make a difference and assist those who are less privileged. His experience out of his ordinary and secured Hyde Park life shakes him to such an extent that he falls into emotional anxiety and depression.

One in a thousand

Out of more than 200 entries, Life out of the Ordinary emerged as the only entry from outside the borders of the two provinces to make a set of 1 000 books recommended by LIASA to be prescribed by public schools as of 2016.

Ntshala was taken aback by the enthusiastic reception which his story attracted. “I am greatly humbled.This means it will rub shoulders with books by great South African authors like Niq Mhlongo, Zukiswa Wanner, Thando Mgqolozana, Zakes Mda and the likes,” he said. He is currently authoring his second novel.

 

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