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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

What did they learn at Stanford University?
2015-11-04

    

Members of the cohort with the
Vice-Chancellor and Rector of the UFS,
Prof Jonathan Jansen

Every year, since 2012, six second-year Kovsies are selected to take part in the elite Stanford Sophomore College Programme at the prestigious Stanford University in the United States. The University of the Free State and Oxford University are the only non-Stanford members of this exclusive course.

From 31 August to 15 September 2015, Farzaana Adam, Cornel Vermaak, Precious Mokwala, Tristan Van Der Spuy, Anje Venter, and Naushad Mayat undertook a three-week long academic exploration of multidisciplinary topics. These students attended seminars aligned with their respective fields of study from which they accumulated a wealth of knowledge.

This year’s cohort reflects on what they learned at Stanford University:

The significance of analyzing technology

One of the key points gathered by Farzaana Adam from the seminar, ‘Great Ideas in Computer Science’, was the necessity not to approach technology at face value. “Computer science goes beyond the technological products and social networks. By analysing the concepts underlying these technologies, many discoveries which have benefitted many fields of study have been made possible.”

Critical thinking in Arts and Science


“By combining different fields of study, one can obtain a greater perspective on the relevant fields,” said Cornel Vermaak, about what he garnered from a seminar titled ‘An Exploration of Art Materials: An intersection between the Arts and Science’. “This greater perspective enables one to evaluate problems critically,” he added.

Visual media substitutes oral narratives

“We were also taught different ways in which to interpret images, and how images influence society. Photography is a way to tell a story without actually having to say anything,” reflected Precious Mokwala, on ‘Photography: truth or fiction’

A lesson in business economics


Tristan Van Der Spuy received pointers pertaining to the stock exchange market    in ‘A Random Walk Down Wall Street’. “We looked at stock markets, and what influenced the stock prices of multiple companies, taking note of what should be looked at when investing in a company.”

Race relations and representation

‘The New Millenium Mix: Crossings between Race and Culture’ exposed Anje Venter to a global perspective on identity. “We explored the new generation of people that have mixed races and cultures, and how they are depicted in media and art.  We analysed the discrepancies and stereotypes of these depictions through film, novel, and short story studies, as well as through field trips to museums and art exhibitions.”

Overcoming the HIV/AIDS endemic


Naushad Mayat realised that “more teamwork and transparency between governments, chemists, social workers, and clinicians will be required for us to stem the flow [of HIV/AIDS],” in view of what he learned in a seminar on ‘HIV/AIDS: A Response to the AIDS Epidemic in the Bay Area’. “It is a daunting task. For the current generation of youth to tackle this epidemic now, we must stand together and be counted,” he added.



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