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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS launches expansions to Biotechnology Building

2015-11-04

Biotechnology Building
Photo: Leonie Bolleurs

To support the strategic focus of the University of the Free State (UFS) on teaching and learning in the field of Biotechnology, the Department of Microbial, Biochemical, and Food Biotechnology introduced upgrades and additions to the value of R23 million to the existing Biotechnology Building on its Bloemfontein Campus. The funding was provided by the Department of Higher Education and Training.

The new section, together with renovations to the existing part of the Biotechnology Building, was opened on Thursday 29 October 2015.

The Department, consisting of three disciplines - Microbiology, Biochemistry, and Food Biotechnology - is extremely diverse. Two of the three disciplines – Microbiology and Biochemistry – are housed in the Biotechnology Building.

Additions and renovations to the Biotechnology Building include:
- Four new research laboratories
- Nine revamped research laboratories

At the launch of the Biotechnology Building were,
from the left: Nico Janse van Rensburg,
Senior Director: University Estates;
Maureen Khati, University Estates,
Prof Nicky Morgan, Vice Rector: Operations
and Ria Deysel, Director: Facilities Management.
Photo: Leonie Bolleurs

The work to the building will have dramatic effects on the quality, as well as the quantity, of postgraduate students. Given the national priority to deliver students, this is very important, particularly at the doctorate level.

Prof Koos Albertyn from the Department said these were the first renovations and expansions done to the building since 1 January 1990. “We welcome the extra space. Forty-six more postgraduate students can now be accommodated in the department,” he said.

Construction took place on the south-western corner of the existing building. Further developments to the building include:
-   Six new offices
-   A lecture hall for 70 students
-   Laboratories that can accommodate 56 postgraduate students

Prof Martie Smit, Academic Head of the Department, said: “This new and refurbished facility enables us to give our best. As academics, we are committed to doing our part in delivering high-quality education at both undergraduate and postgraduate levels to students envisaging a future in biotechnology.”

The James Charles du Preez Seminar Room was also opened at the event. The seminar room is dedicated to Prof Du Preez – who was Head of the Department from October 2002 until the end of 2014. He played a major role in raising funds for upgrading the Biotechnology Building, including the addition of a new wing.

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