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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Dr Karen Lazenby appointed as Registrar: Systems and Administration
2015-11-11


Dr Karen Lazenby, Registrar: Systems and Administration

Dr Karen Lazenby, former Director: Client Service Centre at the University of Pretoria (UP), was appointed as Registrar: Systems and Administration at the University of the Free State (UFS) as from 1 November 2015. She will be responsible for student enrolment, administration and services, and International Affairs.

“We are extremely fortunate to have a person of the calibre and experience of Dr Lazenby to join the senior team to help us create a 21st century student-centred management system using the best technologies available. She is without question the leader in her field, and the UFS is delighted to have her as part of the Kovsie community,” says Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS.

Educational background

Dr Lazenby completed the BA (1992) and Honours (1993) degrees in English (cum laude) at the University of Potchefstroom before pursuing a Diploma in Tertiary Education (1996) and a Master's Degree in Computer Integrated Education (1998) at the University of Pretoria. She obtained a PhD in Education in 2003 on the topic ‘Technology and educational innovation: A case study of the virtual campus of the University of Pretoria’ and an Executive MBA from the University of Cape Town in 2006.

A track record to reckon with


Dr Lazenby started her career in higher education as a lecturer in Communication at the VaalTriangle Technikon in 1994, and was appointed as Head of Academic Staff Development the following year.  A year later, she joined Technikon SA as instructional designer at the Centre for Courseware Design and Development, and in 1997 she was appointed as Manager of Institutional Research. She was subsequently seconded to establish TSA Online and coordinate institutional technology. Dr Lazenby was appointed as a project manager at the department of Education Innovation at the University of Pretoria in 1998 where she implemented WebCT/Blackboard, online applications and payments, and student and lecturer portals (virtual campus). In 2000 she was appointed as Deputy Director: Electronic Education.

She was seconded by the UP Executive to establish the Client Service Centre in 2001 to provide integrated, efficient and effective services to students and other clients of the University. During her time as Director: Client Service Centre, she was inter alia, responsible for information and data governance, the intranet, website and call centre of the university, student recruitment, publications, application for study support, study finance, postgraduate scholarships, student accounts, payments, residence placement, access cards and parking, the graduate career office, and international student division. In 2005, she also acted as Director: Corporate Communication and Marketing.

Her vision for the UFS

“I would like to get the university's student administration to such a point that academic staff can focus on teaching and research. Streamlining the enrolment process so that we may see the necessary yield required in terms of our growth target as a university, is my other goal.” She added that capitalising on the strong international positioning of the UFS achieved by Prof Jansen, is a mission she intends to carry out. "I am grateful for the opportunity to work with Prof Jansen and the senior management team and am delighted to be part of the Kovsie community."

Dr Lazenby has published several articles and presented nineteen papers at international conferences.


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