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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Right to Learn campaign seeks to fund financially needy students

2015-11-11

SRC President, Lindokuhle Ntuli, pledges financial support to the Right to Learn campaign.
Photo: Tango Twasa

In response to the dire need for financial relief for academically deserving students from underprivileged backgrounds, the Student Representative Council (SRC) of the University of the Free State (UFS) launched the Right to Learn campaign on Friday 30 October 2015. The campaign, which aims to counter deregistration, was initiated following the national #FeesMustFall campaign, which gained momentum after students from the University of Witwatersrand first mobilised against the proposed fee increases for 2016.

The SRC’s Projects Committee realised that, although President Jacob Zuma had consented to a 0% increment, the lack of an increase would not eliminate the financial burden currently facing some students.

“The campaign was conceived at the SRC’s strategic planning meeting, and is now spearheaded by the SRCs Projects Committee,” said Letsika Leqoalane, SRC: Academic Affairs. “The campaign was founded on the university's value of ‘Superior Scholarship’ and the SRC’s value of reducing student financial exclusions,” he added.

Students in pursuit of continued access to education

The Right to Learn campaign was established as a supplementary initiative to the #FeesMustFall movement. “The Right to Learn campaign is an initiative to raise funds for students who are facing financial exclusion in the coming year,” said the SRC Academics Affairs officer.

All proceeds will be channeled towards reducing the number of students who will face de-registration in 2016, the SRC textbook bursary, and food bursaries. “This campaign stands on three pillars, namely: no to de-registration, no to student food insecurity, and yes to textbooks,” explained Leqoalane.

A call for support

According to SRC President, Lindokuhle Ntuli, “SRC members have made pledges of no less than R500 each from their own pockets.” The SRC is appealing to the UFS community to make donations into the campaign bank account, and thereafter to email the proof of payment to Ntuli at NtuliL@ufs.ac.za. The account details are:

Account number: 15-7085-0721 ABSA Bank Branch
Reference: SRC FUND
Branch Code: 632005 Cheque Account
Swift code: ABSAZAJJ

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