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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

First Dementia Care Mapper in Africa receives international award

2015-11-17

The first Dementia Care Mapper from Africa,
Dr Sanet du Toit.
Photo: iFlair Photography

“In one facility, four elders who needed minimal assistance to eat were provided with an opportunity to sit at a separate table, and enjoy their breakfast as preferred – that is, to spread bread with butter, jam or marmite; to add their own milk and sugar to their tea.”

Dr Sanet du Toit described a scenario where staff members at an old-age home implemented recommendations she made following an observation she conducted.

“We do not think twice about doing this but, within institutional care settings, these ’normal’ routines are often replaced with practices that could be viewed as ‘time savers’. For example: everyone gets milky, sweet tea to drink,” she explains.

Yet, by creating an environment where the elderly living with dementia were at liberty to determine the amount of milk in their tea, active participation meant an improved well-being.

She was honoured with the International Association of Homes and Services for the Aging (IAHSA) Award for Excellence in Applied Research on 1 September 2015, at a joint conference held by the Aged & Community Services Australia (ACSA) and IAHSA in Perth.

This exceptional Occupational Therapist from the University of the Free State (UFS) emerged as the first Dementia Mapper from Africa. Dementia Care Mapping is a method used internationally to assess with the purpose of improving the quality of care given to residents in institutionalised settings.

The IAHSA award acknowledged her person-centered care training and research in South African residential care facilities while working at the UFS as a senior lecturer from 2003 to 2013. Currently, she is based at the University of Sydney, but remains an affiliated lecturer at the UFS Department of Occupational Therapy.

In 1992, she graduated with a BA in Occupational Therapy at the UFS, and went on to further her studies at various institutions. Also, she is one of the founding directors of the Eden Alternative South Africa, an advocacy for older persons’ rights within old-age homes. Over the years, Dr du Toit has won numerous awards for her research.

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