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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof Heidi Hudson appointed to international Committee on the Status of Women

2015-11-24

Prof Heidi Hudson is looking forward to advancing women scholars globally
Photo: Supplied

Prof Heidi Hudson, director of the Centre for Africa Studies at the University of the Free State, was recently appointed by the President of the International Studies Association (ISA) to serve on the Committee on the Status of Women from March 2016 to April 2018.

Representing over 100 countries, ISA has more than 6 500 members in North America and internationally, and is the most respected and widely-known scholarly association in the field of International Studies.

She anticipates that her role on the committee will complement her research interests in feminist security theory and practice in Africa. “I am looking forward to playing a part in the advancement of southern scholars, and the promotion of their voice in global academe.”

Prior to Professor Hudson’s appointment, she served as a member of the executive of the Feminist Theory and Gender Studies (FTGS) Section of ISA.

Representing women of the world in academia

The Committee on the Status of Women has the task of reviewing the status of women in the profession, and making recommendations to the president and the Governing Council of ISA on ways of tracking and increasing the status and visibility of women in the profession.

“Some of the goals of the committee for the 2014 to 2016 period include reaching out to women scholars in the global south; creating an ISA networking website for women scholars; and surveying perceptions of the international relations climate and its needs,” said Prof Hudson. It is also responsible for “tracking gender balance within ISA and its journals, and supporting ISA regions in fulfilling the mission of the Committee on the Status of Women,” she added.

Connecting scholars globally since 1959

The ISA has been the premier organisation for connecting scholars and practitioners in fields of international studies, and promoting research and education. ISA cooperates with 57 international studies organisations in more than 30 countries, is a member of the International Social Science Council, and enjoys non-governmental consultative status at the United Nations.

Prof Hudson’s research interests concentrate on discursive and material gender deficits of liberal peacebuilding in the post colony, amongst other subjects. She is also co-editor of International Feminist Journal of Politics.

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