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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Master’s student awarded Mandela Rhodes scholarship

2015-11-25

Candice Thikeson’s name will be added to the Mandela Rhodes Scholars book
Photo: Valentino Ndaba

Candice Thikeson was recently selected as the only 2016 Mandela Rhodes Scholar from the University of the Free State. She is one of 50 young African postgraduate students, eager to contribute positively to the educational development of the continent.

The Mandela Rhodes scholarship is a fully-funded postgraduate scholarship awarded to promising future leaders by the Mandela Rhodes Foundation. It is named after the former president of our country, Nelson Mandela, and Cecil Rhodes, who was known for his business skills and political influence in South Africa. Instituted in 1999, the scholarship aims to advance scholars who demonstrate the principles of Leadership and Reconciliation embodied by Mandela and Rhodes’s legacy, as they relate specifically to Education and Entrepreneurship.

Thikeson expects the programme will educate her on how to integrate the four pillars in relation to her field of study.

For Thikeson, earning the scholarship served as an endorsement of her dream of becoming an academic. “I want to obtain a PhD, lecture at a university, publish papers, and speak at conferences,” she related. “I also want to produce academics, I want to mentor young people,” she added.

Her academic journey began in 2011 when she pursued a BA Fine Arts degree for a year. Thikeson then transferred to a BA General degree which she completed over two instead of the standard three years. She went on to study an Honours degree in Art History and Visual Culture Studies. In the same year, she travelled to Rijksuniversiteit Groningen (University of Groningen) in the Netherlands as part of an exchange agreement between the university and the UFS, where she completed her mini-dissertation in four months. Both her BA and Honours were passed with distinction. Currently, Thikeson is pursuing a Masters degree at the Department of Art History and Image Studies under the supervision of Prof Suzanne Human.

Some accolades to her name include the Jan Teurlinckx Prize for the best student in Art History (2011), the David Jacobs Prize, awarded to the best student in Philosophy (2013), and the Richard Miles Prize, presented by the Dean of the Faculty of the Humanities (2013). Thikeson was also selected as a member of the Golden Key Honour society in 2012, for her consistent academic excellence.

Last year, Lehlohonolo Mofokeng, Zola Valashiya, and Tumelo Morobane made the UFS proud by graduating as the class of 2015 Mandela Rhodes Scholars.

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