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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

State-of-the-art audio-visual studio up and running at UFS
2015-11-25

The state-of-the-art audio-visual studio that was unveiled in the beginning of this year reaped its first crop during a historic moment. On Wednesday 28 October 2015, the eight pilot students in the Postgraduate Programme in Film and Visual Media, which was launched at the beginning of this year, had their first big screen experience. Eight films were premiered in one night at the University of the Free State (UFS) Bloemfontein Campus.

An intimate movie theatre was brimming with friends and family of the students, their lecturers, and judges who doubled as moderators. This was no ordinary motion picture viewing. The apprentice filmmakers’ productions were undergoing formal external examination.

Judge by a legend

Katinka Heyns
critiqued the student’s final products. Heyns is a renowned filmmaker, actress, director, producer, and founder of the production company, Sonneblom Films. She has numerous awards to her name, including the Career Contribution and Innovation Award, Legendary Award for Woman in Film and Television, and Medal of Honour for Paljas, which were presented by the Absa Klein Karoo Nasionale Kunstefees (KKNK), International Crystal Award, and South African Academy for Science and Arts, respectively.

Johanet Kriel and Chris Vorster from the film school also assisted as moderators.



The cinema exam

Each student had 20 minutes to provide a synopsis for the viewers, and screen the movie. At the end, The Secret of the Golden Flower, written and directed by Rudiker Janse van Rensburg, and The Nexus Effect, written and directed by Gawie Myburgh were judged the best movies “Both films had had clear and creative story lines, a solid structure, and quality editing,” said Chris Vorster.

Despite technical teething problems, all the students showed a great deal of talent and passion for filmmaking. “Given the time constraints and technical challenges, I’m very relieved that we actually got films on screen. They all impressed me with their creativity. Mission accomplished,” added Vorster.

The films

• The Blood of Barbara (Yvonne Allwright)
• Diary of an Oreo (Nonsindiso Qwabe)
• GeFop! (Hendrik Cronje)
• The Nexus Effect (Gawie Myburgh)
• The Secret of the Golden Flower (Rudiker Janse van Rensburg)
• Well ain’t that a Coinkydink?! (Rethabile Radebe)
• What Lurks in the Dark…(Rese Moore)

(Photo caption: Front row from left: Nonsindiso Qwabe, Suné van Heerden, Theresa Moore, Gawie Myburgh. Middle row: Rudiker Janse van Rensburg, Hendrik Cronjé, Yvonne Allwright, and Rethabile Radebe. Back: lecturer: Chris Vorster.)

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