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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Cardiovascular Research Centre a South African solution to continental crisis

2015-11-30

From left are: Dr Robert Kleinloog, president of the Society of Cardiothoracic Surgeons of South Africa, Prof Jonathan Jansen, Vice-Chancellor and Rector of the University of the Free State (UFS), Prof Robert Frater after which the Robert W M Frater Cardiovascular Research Centre was named and Prof Francis Smit, head of Cardiothoracic Surgery at the UFS, at the launch of the new centre.
Photo: Johan Roux

“You don’t have to be in New York or any big city in the world to establish a cardiovascular centre that delivers work of world standards. I’ve learned that extraordinary things are achieved by ordinary people who apply themselves accordingly. This research centre is a South African solution to a continental challenge”.

These were the words of Prof Robert Frater at the opening of the new Robert W M Frater Cardiovascular Research Centre in the Department of Cardiothoracic Surgery at the University of the Free State (UFS) School of Medicine.

The centre, one of only two of the kind in the country, will focus on bioengineering and cardiovascular research. It was opened on Wednesday 18 November 2015 in the Francois Retief Building on the Bloemfontein campus.

The centre is named after Prof Robert W.M Frater in recognition of his vast contribution to the UFS. He is internationally recognised for his outstanding academic, clinical, and scientific contributions to cardiac surgery. Prof Frater has also been actively involved in research activities of the Department of Cardiothoracic Surgery for the last 10 years. In 2011, he received an honorary doctorate from the UFS.

Under the leadership of Prof Francis Smit, head of Cardiothoracic Surgery, the department has been described as a dynamic unit at the forefront of meeting the different changes in Southern Africa while maintaining an excellent clinical and academic track record.

At the opening, Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, thanked Prof Frater for his presence at, involvement in, and support of the UFS. “I am looking forward to working in collaboration with the department to make this university a research centre of excellence in the continent”, he said.

The centre has existing endeavours already in operation, including Population projects, Clinical studies, and Clinical pathology, to name three. In collaboration with the Central University of Technology, the University of Stellenbosch, and Charite University of Berlin, among numerous others, the centre will be an appropriate help to an African challenge.

Its introduction promises advanced research outcomes with the potential to make the Department of Cardiothoracic Surgery a world-class competitor.

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