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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Psychologist honoured for lifelong contribution
2015-12-09

Prof Dap Louw, distinguished professor and forensic psychologist from the University of the Free State, receives a Lifelong Achievers Award from the University of Johannesburg. From left is: Prof Theo Veldsman, head of the Department of Industrial Psychology and People Management at UJ, prof Louw, prof Deon de Bruin, Department of Industrial Psychology and People Management at UJ, and prof Daneel van Lill, dean at Faculty of Management at UJ.
Photo: Jan Potgieter, UJ

 

It is always good to be honoured by your own university, but it is even more special to be honoured by another university, according to Prof Dap Louw, distinguished professor and forensic psychologist from the University of the Free State (UFS), on an award he received from the University of Johannesburg (UJ).

On 5 November 2015, Prof Louw received the prestigious Lifelong Achievers Award from the Department of Industrial Psychology and People Management at UJ in recognition of the major contribution he has made during his career in psychology. He was one of two recipients of the award during this year’s UJ Top Achievers Awards Ceremony.

Prof Louw had great appreciation for his students and colleagues at the UFS, without who he would have been “without arms”.

Worthy legacy

The Lifelong Achievers Award is presented to retired academics that have, over their careers, consistently made significant contributions to their field, nationally and/or internationally, and have left behind a worthy legacy.

According to the description for the award, the recipient has left behind a legacy in his or her specific field which is gratefully acknowledged by all past, present and upcoming professional colleagues, students, clients and other stakeholders.

This description concludes with: “We are a better science and profession because of you”.

Career full of highlights

Prof Louw is the author or co-author of over 100 articles in accredited national and international journals, and he is an accredited NRF researcher.

He is the principal author and editor of several textbooks currently prescribed by 12 universities in South and Southern Africa. It is estimated that, over the years, more than 100 000 students have received their training via textbooks he has written with his wife, Prof Anet Louw.

Prof Louw holds a master’s and doctoral degree in Criminology, and a master’s and doctoral degree in Psychology. He is the only person in South Africa with these qualifications.
During his career as forensic psychologist, Prof Louw has testified in many familiar criminal cases in South Africa and Namibia.

The Academy of Science of South Africa presented him with the Stals Award for Psychology and he was honoured by The National Honor Society in Psychology in the USA as well.

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