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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

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Graduates challenged to fulfil their leadership obligations

2015-12-14

Procession frontline: seen making their way to the graduation ceremony are from left: Dr Khotso Mokhele (Chancellor of the UFS), Prof Busisiwe Bhengu (Chairperson of the South African Nursing Council), and Prof Jonathan Jansen (Vice-Chancellor of the UFS).
Photo: Johan Roux

The time for one-dimensional discourse was over, said Professor Busisiwe Bhengu, the guest speaker at this year’s Summer Graduation. Practical implementation of change was the step forward in forging the path into a brighter South Africa future.

During both the morning and afternoon ceremonies held at the University of the Free State (UFS) Bloemfontein Campus on 10 December 2015, the Chairperson of the South African Nursing Council, and Associate Professor at the University of KwaZulu-Natal, challenged the newly-graduated alumni to rise to the occasion, and be a part of the solution to our country’s diverse challenges.

Some of the pervasive hardships she highlighted were human immunodeficiency virus (HIV) and tuberculosis (TB), the escalating number of orphans and child-headed households, and the human resource shortages resulting from an ageing generation which is exiting the employment system through retirement.

Prior to dissolving the congregations, Dr Khotso Mokhele, the Chancellor of the UFS, said: “I was caught by the leadership challenge she [Prof Bhengu] threw out at the graduates because we indeed need courageous, creative and innovative leaders moving forward,” he said.

Dr Mokhele touched on South Africa’s dwindling economy, the leadership issues engulfing the government currently, the #FeesMustFall movement, and how students led a difficult dialogue and dictated the country’s trajectory as regards education, as well as the water scarcity we are facing. In closing, he warned that the graduates had lost the luxury of feeling led because of the fact that they now have a leadership obligation to fulfil.

Highlights of the day

Amongst 102 graduates from the UFS School of Medicine were two brothers from the Free State, Johann and Rudi Westraad who followed each other’s passion to become doctors.

Deputy Registrar at the UFS, Elna Van Pletzen, graduated with a Master’s in Higher Education Studies. Her thesis titled ”The implications of current legislative changes for academic freedom and institutional autonomy of South African higher education institutions”, focused on the amendment of Higher Education and Training Laws Amendment Act of 2012. In it, she tackled the subjects of academic freedom and the relationship between government and higher education institutions. Coincidently, her research was produced at a time when the subject of university autonomy was on the national agenda.

The occasion was not only a celebration of the students; teachers were also recognised for their dedication to quality education. Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS congratulated Dr Louise van den Berg (Faculty of Health Sciences) as well as Naquita Fernandes and Salomien Boshoff (both from the Faculty of Economic and Management Sciences) for their outstanding achievements. At a recent ceremony, Dr Van den Berg received the Vice-Chancellor’s Award for an individual teacher, and the Vice-Chancellor’s Award for the best teaching team was presented to Fernandes and Boshoff.

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