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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Researcher in Otorhinolaryngology advocates education in deafness and hearing loss
2015-12-17

Description: Dr Magteld Smith  Tags: Dr Magteld Smith

Dr Magteld Smith

The annual International Day of Persons with Disabilities falls on 3 December. Statistics reveal that 7.5% of the South African population suffer from some form of physical disability.

More than 17 million people in South Africa are dealing with depression, substance abuse, anxiety, bipolar disorder, and schizophrenia - illnesses that round out the top five mental health diagnoses, according to the Mental Health Federation of South Africa. The South African Federation for Mental Health is the umbrella body for 17 mental health societies and numerous member organisations throughout the country.

On disability, world-renowned author Helen Keller, who was both deaf and blind, once said that the problems that come with being deaf are deeper and more complex than those of blindness, and is a much worse misfortune. For it means the loss of the most vital stimulus - the sound of the voice that brings language, sets thoughts astir, and keeps us in the intellectual company of man.

According to Dr Magteld Smith, lecturer and researcher in the Department of Otorhinolaryngology at the University of the Free State (UFS), hearing loss of any degree at any age can have far-reaching psychological and sociological implications which affect an individual’s day-to-day functioning, and might prevent him or her from reaching their full potential. She says that even though advancements have been made in aiding deaf persons, there’s still considerable room for improvement. She’s making it her mission to bring about changing the stigmatisation around deafness, and the different choices of rehabilitation.

Dr Smith was born with bilateral (both ears) severe hearing loss, and became profoundly deaf, receiving a cochlear implant in 2008. Not letting this hinder her quality of life, she matriculated in 1985 at a School for the Deaf in Worcester. Today she is the only deaf medical-social researcher in South Africa.

Her research focuses on all aspects of deafness and hearing loss. Through first-hand experience, she knows that a loss of hearing can be traumatic as it requires adjustments in many areas of life which affect a person’s entire development. However, she has not let her deafness become a stumbling block. She has become the first deaf South African to obtain two Master’s degrees and a PhD, together with various other achievements.

Her work is aimed at informing and educating people in the medical profession, parents with children, and persons with various degrees and types of hearing loss about the complexities of deafness and hearing loss. She believes that, with the technological advancements that have been made in the world, deaf people can become self-sufficient and independent world changers with much to contribute to humanity.

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