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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Dr Johann Rossouw receives 2015 ATKV SA Academy Award for his work in Philosophy
2015-12-18

Description: Dr Johann Rossouw  Tags: Dr Johann Rossouw

Dr Johann Rossouw

Dr Johann Rossouw, Senior Lecturer in the Department of Philosophy at the University of the Free State, was recently selected as one on the winners of the 2015 ATKV SA (Afrikaanse Taal- en Kultuurvereniging) Academy Awards. Dr Rossouw was one of only six winners that were honoured nationwide for their academic articles.

ATKV SA Academy Award

This award has immense value for Dr Rossouw, since “it’s proof that original endemic thinking is still valid today, despite the massive pressure on Afrikaans. It also undermines the parochial view that English is the only language in which thought takes place.”

The annual ATKV SA Academy Awards honours six Afrikaans articles that are published in accredited journals in a specific year. Four of the prizes are awarded for articles in the Humanities and two for articles in the Natural Sciences. The South African Academy for Science and Arts handled the selection process.

First theological-philosophical criticism on Stiegler

Dr Rossouw was honoured for two articles in the Humanities that were published on Litnet Academic. The articles deal with the theological-philosophical approaches of the first two volumes of Bernard Stiegler's influential La Technique et letemps (Technics and Time) trilogy. “Stiegler wrote the trilogy in conversation with Heidegger's Being and Time,” Dr Rossouw says. “With Heidegger claiming that the technique closes off our world, Stiegler argues that the technique helps to unlock and establish our world as a unique kind of memory in certain conditions. That is why Stiegler argues that the technique is the life lived through other means than life itself.”

The essence of Dr Rossouw's criticism against Stiegler is that he “pursues Christianity through means other than Christianity itself. To my knowledge, this is the first theological-philosophical criticism on Stiegler, and to all intents and purposes the first criticism on his work, with one or two exceptions.”

 

 

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