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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Success of Schools Partnership Programme embodies essence of UFS
2016-01-04

Description: Schools Partnership programme Tags: Schools Partnership programme

The everyday function and subsequent success of the SPP have come to embody the very essence of the UFS: inspiring excellence; transforming lives.

Addressing the urgent need for quality education at school level, the University of the Free State (UFS) established the Schools Partnership Project (SPP) in 2012. The aim of the project has been to turn ineffective schools into institutions producing outstanding results, thereby increasing the number and quality of first-year students at the UFS.

Within three years, the SPP has grown to include 68 primary and secondary schools across the Free State and the Sterkspruit area in the Eastern Cape. The programme is headed by Dr Peet Venter and run from the UFS South Campus. Expert mentors assist teachers and principals at these schools on a weekly basis, helping them to excel at their core functions. The programme’s success has been phenomenal.

Learner results from the SPP schools show a marked improvement compared to previous years. Teachers report that they have gained a broader understanding of the subjects they teach. “The university is doing a great job with this programme,” says one of the teachers. “We have developed a lot. We really appreciate this partnership.” Teachers not only gain substantial expertise in areas of planning, presentation, and subject knowledge; an increasing number of them have been receiving promotions, too.

The principals experience similar positive results, and regard the SPP as a productive contribution to their schools. The project has also established closer cooperation between principals and schools. This enables them to achieve common goals, share knowledge, and deal with challenges together.

An added spin-off of the programme has been the increased involvement of parents and care-givers. “We experience much more involvement from the community,” says mentor Danie Nieuwenhuizen. Parents start to take it upon themselves to tidy school grounds, care for vegetable gardens, and prepare food at school feeding schemes. Even the Sustained Silent Reading programme – that supplies magazines to learners – is now having an impact on households and communities. Many homes have never had magazines or other reading material before the reading programme.

The everyday function and subsequent success of the SPP have come to embody the very essence of the UFS: inspiring excellence; transforming lives.

 

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