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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

SRC raises over R1 million for UFS underprivileged students

2016-01-18

R1.2 million has been raised by the University of the Free State’s (UFS) Student Representative Council (SRC) under the Right to Learn (R2L) campaign banner.

The SRC launched the R2L campaign on 30 October 2015,following the first wave of the #FeesMustFall movement protests against a proposed increase in tuition fees. The campaign was initiated to ensure that academically-deserving underprivileged students do not have to bear the brunt of deregistration, food insecurity, and the lack of textbooks.

To date, the student leaders have taken it upon themselves to appeal to lecturers, businesses, the community, and students alike to support its campaign. Each SRC member pledged R500 from their own purses when the campaign was launched.

Looking back at the #FeesMustFall movement

To the #FeesMustFall movement, which had gained momentum and resulted in a shutdown of many campuses across the country, President Jacob Zuma responded with a statement announcing a 0 % increase.

At the launch of the campaign, Lindokuhle Ntuli, the UFS SRC President, made a commitment to source financial aid for needy students.

“Even though the president said no fees will increase this year, we are still faced with the same challenges. No students who qualify should be de-registered this year. It is up to us to raise funds for the poor students to ensure that they get their right to education.”

Forward to the future: #AccessMustRise

By 4 April 2016, the SRC’s goal is to accumulate financial relief worth R5 million to counter the growing financial aid demand.

Given that more South Africans are extending a helping hand, the SRC President is adamant about gathering the sponsorships in two months. “It is possible if we push to market the campaign to gather R4.8 million,” said Ntuli.

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