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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS trains Kovsies to become great in world terms – Prof Jonathan Jansen

2016-01-19

First-year students from the University of the Free State (UFS) recently attended the welcoming ceremony at the Red Square of the Bloemfontein Campus.
Photo: Johan Roux

The University of the Free State (UFS) does not train Kovsies to become great in Bloemfontein or even South Africa. The UFS trains them to become great in the world.

With these words, Prof Jonathan Jansen welcomed the first-year class of 2016 to the “home of Wayde van Niekerk, Rolene Strauss, and the 2015 Varsity Cup rugby champions”.

Prof Jansen, Vice-Chancellor and Rector of the UFS, welcomed the newcomers to the start of the “best time of their lives” on 15 January 2016 at the Red Square of the Bloemfontein Campus. First-years and their parents attended the annual welcoming ceremony.

Prof Jansen congratulated the students on choosing the UFS, and on being part of the elite group that was selected to study at the university.

The UFS received 25 142 applications from newcomers, he said, although there are only about 8 000 places. In 2015, there were roughly 17 500 applications.

He said it was also the most diverse group of applications the UFS had ever received.

Access to education

According to Prof Jansen, the UFS is committed to helping poor students gain access to education, no matter what their background or the colour of their skin.

Lindokuhle Ntuli, the UFS Student Representative Council (SRC) President, said higher education should be more accessible. He said South Africa has allowed education to become commercialised.

“The sooner we as a country realise education isn’t an expense, but rather an investment, the better,” he said.

UFS campaigns

Prof Jansen thanked the UFS SRC for the Right to Learn (R2L) campaign. Launched by the SRC on 30 October 2015, this campaign has already raised R1.2 million to help academically-deserving underprivileged students to study.

“I have launched a campaign myself to raise R100 million between now and September. About 50% of my time will go into this,” Prof Jansen said.

“I will work tirelessly with Lindokuhle and the SRC to raise money.”

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