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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Fundraising while having fun

2016-01-25

With the Receive And Give (RAG) Community Service processions and festival around the corner, the public can expect loads of festive fun for the whole family.

Over the years, RAG has grown in popularity among the Bloemfontein community as the official launch of the social calendar. At the beginning of each year, the streets come alive with thousands of students from the University of the Free State and their colourful floats. They are joined by spectators from all over the city.

Float building

The ‘Cartoons, Animation and children snacks’ theme for 2016, has kept first-year students and RAG representatives working tirelessly since 18 January 2016, building majestic floats that are sure to entice on-lookers.

Ritsim Magazine sales

The annual RAG publication, Ritsim, is now available for only R25 a copy. All proceeds are channelled into different charities across the country.

This year, in a joint venture between Kovsie RAG and Volksblad, approximately 8000 Ritsims will be sold as a package deal with all the newspapers in the Northern Cape and Free State.

The processions

About 10 000 meals will be distributed to needy residents of the Heidedal and Mangaung communities at the Twin City mall after the morning procession.

Floats will be judged prior to the morning procession. The float winners will be announced at 17:00 at the RAG Farm, and the winners will lead the afternoon procession.

Date: 30 January 2016
Times: 10:00 (morning procession) and 18:00 (afternoon procession)
Route for morning procession: Pelonomi Hospital to Twin City mall
Route for evening procession: Tempe traffic light at Nelson Mandela Drive to Old Grey Sports Grounds

The festival

After a day of chanting, collecting donations, and feeding the community, the RAG festival will round out the day with good music. Both young and old will be entertained by well-known and vibrant artists such as Vusi Mahlasela, Karen Zoid, and Francois van Coke.

Date: 30 January 2016
Time: Gates open at 16:00
Place: Old Grey Sports Grounds

Tickets are available from Computicket and at the gate for R100 per person and R50 per student or children under 12 years of age.

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