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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof Luyt says young researchers should not allow circumstances to determine their future

2016-02-01

Prof Riaan Luyt, an NRF B-rated researcher
Photo: Supplied

Young researchers, who spend their life at a disadvantaged and rural campus like the University of the Free State’s Qwaqwa Campus, should not be deterred from achieving their dreams.

This is the view of Prof Riaan Luyt, former Assistant Dean in the Faculty of Natural and Agricultural Sciences, who achieved his B-rating by the National Research Foundation (NRF) late in 2015. This was by far the highest-ever rating on the Qwaqwa Campus.

“When I moved to the Qwaqwa Campus many years ago, having had the opportunity to do a post-doctoral fellowship in Polymer Science at the Leeds University in the United Kingdom, I was determined to get the Department of Chemistry off the ground, and to embark on serious research,” said Prof Luyt, who is now the Affiliated Professor in the Department of Chemistry and Research Associate Professor at the Centre for Advanced Materials, based at Qatar University.

“It was through sheer determination that I managed to obtain enough funds to equip a decent research laboratory. There were many obstacles over the years, but I managed to attract more and more postgraduate students and published more,” he said.

At first, Prof Luyt was not successful with his NRF-rating applications.

“My first couple of attempts to get rated produced no success. I was then awarded a C3-rating, which was later followed by C2 and then C1,” he added. “Getting a B-rating is the highlight of my research career. It shows that it can be done. Young researchers should not allow their past or present circumstances, or their work environment to stand on their way,” said Prof Luyt, who has supervised 38 master’s and doctoral students as well as 11 postdoctoral fellows. He has also published 185 papers in international and accredited journals.

Although abroad, Prof Luyt will continue to supervise eight postgraduate students at the Qwaqwa Campus.

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