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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A degree means nothing if you are not a decent human being, Vice-Chancellor tells first-years
2016-02-01

Description: Qwaqwa first-year welcoming 2016 Tags: Qwaqwa Campus

The 2016 Qwaqwa Campus first-year students received one of the warmest welcomes when the entire Rectorate and other senior UFS officials arrived to welcome them.

Leading the delegation was the Vice-Chancellor and Rector, Prof Jonathan Jansen, whose captivating message was well received by students and those parents who were in attendance.

“What keeps me going is your determination to come to the University of the Free State to start your life. You have done the right thing; do not forget that you are smarter than you think,” said Prof Jansen.

“Each one of you has a story to tell. You had to overcome poverty, disadvantage and abuse,” he said.

Prof Jansen encouraged first-year students to do more than just obtain a degree whilst at the university.

“This university is good not only in ensuring you get the best qualifications. Graduating and continuing to disrespect women is not good enough. Graduating and still continuing to be biased against gay people is not good enough. Getting a degree and still thinking you are better than others just because you have money is not good enough. A degree means nothing if you are not a decent human being,” he added.

In his welcoming message, the SRC President, Paseka Sikhosana, highlighted the importance of academic excellence that is backed by human embrace.

“Human embrace and academic excellence are two very important aspects that we strive for. Five of our members will be graduating this year whilst six are Golden Key members. And we have a very huge task of bringing our campus closer to the community and the community closer to our campus in an attempt to make a difference in those communities,” he said.

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