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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Female-headed households more prone to economic strains due to rainfall variations
2016-02-02

Description: Martin Flatø  Tags: Martin Flatø

Martin Flatø
Photo: University of Oslo press

Research shows that a total of 41 % of South African (SA) households are led by women, and these households are twice as likely to be poor compared to other households.

Martin Flatø spent three months at University of the Free State (UFS), researching how female-headed households in our country are affected by variations in rainfall, which cause crop failures with their implications for rural economies.

He is a PhD student from the University of Oslo in Norway who was part of the 2014/15 Southern African Young Scientists Summer Programme (SA-YSSP) that was hosted by the UFS last year.

Flatø formed part of a group of international scholars who conducted research on how families led by females are affected by climate change. The group focused on the implications of the weather on crop failures and rural economies. Gender and household structures were studied to determine ways in which they are affected by economic fluctuations.
 
The research group’s preliminary findings indicate that female-headed households are more vulnerable to rainfall variation than households where there are adult residents or workers of both genders.

In view of the current water shortage in the Free State, as well as scientists’ projections that our country will be among the regions hardest hit by climate change in terms of a surge in temperature, Flatø’s collaborative research has substantial relevance.|

Grooming first class scientists
The SA-YSSP is a joint initiative of South African National Research Foundation and the International Institute of Applied Systems Analysis (IIASA). Its main aim is tackling challenges faced by the world at large and South Africa in particular.

Out of 24 PhD students from 18 countries and various academic disciplines, Flatø emerged as one of only three scholars to be awarded the Systems Analysis Scholarships for his outstanding science at the end of the programme.

World class mentorship
Prof André Pelser and Dr Raya Muttarak were Flatø’s SA-YSSP supervisors. Prof Pelser, of the UFS Department of Sociology, is a leading academic on population processes, and how they relate to local environmental issues in South Africa. Dr Muttarak is a research scholar at IIASA in Austria.

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