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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New Academic Head at South Campus to expand distance learning programmes into the global arena
2016-02-10

“Critical area of focus: Diversify provision, based on open learning principles, to improve learning opportunities across the post-school education and training sector” - SA Department of Higher Education and Training Strategic Plan 2015/16-2019/20

Open and distance learning (ODL) programmes will play a critical role in shaping the landscape of higher education. Not only does the South African Department of Higher Education and Training emphasise the importance of ODL, it is also contained within the United Nations’ Sustainable Development Goals. And now the University of the Free State (UFS) is becoming a major role player in the field through the cutting-edge ODL programmes offered by the South Campus.

Description: Jean Grundling  Tags: Jean Grundling

Jean Grundling has recently been appointed as the Academic Head of the South Campus.

At the helm of these programmes is the recently-appointed Academic Head of the South Campus: Jean Grundling. According to the new organisational structure of the South Campus, the Academic Head reports directly to the Campus Principal: Dr Daniella Coetzee.

“My role,” says Grundling, “focuses on developing and monitoring processes that will enable effective and efficient implementation of the three pillars of ODL.” These three pillars consist of:

• the design and development of quality learner-centred learning materials and tools during their ODL journeys;
• the selection, appointment, and development of competent facilitators to guide, coach, tutor, and support students; and
• the integration of administrative processes that will enable and support students to study at their own pace, place, and in their own time.

“Goal 4: Ensure inclusive and equitable quality education, and promote lifelong learning opportunities for all.”
United Nations Sustainable Development Goals

As part of her personal vision, Grundling would like to see the South Campus grow and develop into an institution that offers quality ODL programmes not only nationally, but globally. “I would like the South Campus to become an agent of social transformation in South Africa.”

Ultimately, Grundling’s wish is for the South Campus to contribute to the development and empowerment of people so that they can play a positive role in society.

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