Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Lithium-ion batteries research set to improve ordinary lives

2016-02-11

Description: Dr Lehlohonolo Koao Tags: Dr Lehlohonolo Koao

Dr Koao is making a much-needed contribution in improving lives of ordinary people through his research on lithium-ion batteries.

The future of relevant and top-notch scientific research at the Qwaqwa Campus is in good hands. Dr Lehlohonolo Koao is one of the five members of the Vice-Chancellor’s Prestige Scholars Programme (PSP) on the Qwaqwa Campus.

The need to improve the efficiency of heating mechanisms in his immediate community in Qwaqwa, and the support he receives from the PSP, have become catalysts for his current research project on lithium-ion batteries. According to Dr Koao, the study will focus on producing batteries that last longer, store more energy, are cheaper to manufacture, and are environmentally friendly when being disposed of. These are key factors in solar energy.

‘’The majority of households in my neighbourhood have benefited from the government’s project of providing households with solar panels to help with lighting, cooking, and heating without worrying about the ever-increasing electricity costs,’’ said Dr Koao.

‘’Since my arrival in the area, I have realized that the heat absorption rate of the batteries used by solar panels is not enough. As a result, these batteries also lack enough power to sustain the supply throughout the day, especially on a cloudy day,’’ he said.

His research project focuses on improving the efficiency of lithium-ion batteries that are now commonly used in portable electronics, such as cell phones and laptops. This kind of battery is rapidly replacing the usual lead-acid batteries. Dr Koao’s determination to contribute towards a safer and more efficient heating absorption system has made him move away completely from his PhD study on lighting material.

‘’My previous study was on reducing the power usage on domestic and industrial lights as they use more electricity. This study, on the other hand, will enhance power retention in the batteries for improved daily life since cell phones, solar panels, and laptops, to mention only a few, are now a way of life,’’ he added.

Dr Koao is a Senior Lecturer in the Department of Physics, where he specializes in solid state materials.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept