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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Fun in the sun at first-years swimming gala
2016-02-12

Description: Swimming Gala Tags: Swimming Gala

Residences of the University of the Free State showed off their colours and cheered their swimmers to victory at the first-year swimming gala on the Bloemfontein Campus.
Photo: Johan Roux

The first-year students’ swimming gala is always a much-anticipated event, especially after the participants have rubbed shoulders with residence competitors at the first-year athletics. This year’s gala, which took place on 5 February 2016 at the Lindsay Saker swimming pool on the Bloemfontein Campus, proved as exhilarating as always.

The body painting competition, held through the University of the Free State Student Representative Council (SRC) portfolio of Media & Marketing, and sponsored by ABSA, was re-introduced.

Colleges in colour

Before the swimming, spectators had the opportunity to look at the body painting creations presented by each college. Colleges chose one of ten themes randomly. Nonetheless, true artistry was on display. South College were awarded the body painting floating trophy.

When asked about this year's competition, SRC Media & Marketing, Peo Segano, had this to say: "I questioned the relevance of it, but I got the opinion of the residence committees and how they felt about it.
“The majority voted for it to be re-introduced, and ABSA was more than happy to sponsor the paints and some treats.”

Description: Swimming gala video photo Tags: Swimming gala

Video clip

Soon after that, it was down to the business. The swimming started, and each residence was cheering ecstatically for their fellow freshmen as everyone waited in anticipation to see who would be crowned the kings or queens of the water.

Kings and queens of the water

Although many had sung their voices away, they continued to show their spirit through dance and movement. Then, residences were ready to hear whether it had all paid off. Armentum showed consistent effort in this regard, thus ensuring them of the spirit trophy.

To close off the festivities, the final announcements were made. Sonnedou was crowned the female residence winners, while Abraham Fischer (Vishuis) received the title of best male residence.

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