Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Einstein's gravitational waves as creative as Bach's music, says UFS physicist

2016-02-19

Description: Gravitational waves Tags: Gravitational waves

Profile of the gravitational waves of the colliding black holes.

Prof Pieter Meintjes, Affiliated Researcher in the Department of Physics at the University of the Free State, welcomed the work done by the Laser Interferometer Gravitational-Wave Observatory (LIGO) science team.

For the first time, researchers from two of the American Ligo centres, in Washington and Louisiana respectively, observed gravitational waves directly, 100 years after Albert Einstein said they existed. "My study field in astrophysics involves relativistic systems. Therefore, Einstein's view of gravity is crucial to me. I consider the theory as the highest form of human creativity - just like the music of JS Bach. Over the past 100 years, the theory has been tested through various experiments and in different ways.

“The discovery of gravitational waves was the last hurdle to overcome in making this absolutely unfaltering. I am therefore thrilled by the discovery. It is absolutely astounding to imagine that the equations used to make the predictions about the gravitational-wave emissions when two gravitational whirlpools collide - as discovered on 14 September 2015 by LIGO - are basically Einstein's original equations that were published way back in 1916 - in other words, 100 years ago.

“The LIGO detectors have been operational since the early 1990s, but they had to undergo several stages of upgrades before being sensitive enough to make detections. LIGO is currently in its final stage, and is expected to function at optimal sensitivity only within a year or two. To be able to conduct the measurements at this stage is therefore a fantastic achievement, since much more funding will certainly be deposited in the project,” Prof Meintjes says.

Description: Prof Pieter Meintjes Tags: Prof Pieter Meintjes

Prof Pieter Meintjes
Photo: Charl Devenish

The search for gravitational waves by means of the Square Kilometre Array (SKA) is one of the focus points in research by both Prof Meintjes and PhD student, Jacques Maritz. This involves the study of radio signals from pulsars that might show signs of effects by gravitational waves. They are looking for signs of gravitational waves. The gravitational waves discovered and studied in this manner would naturally vary much more slowly than the signal discovered from the two colliding gravitational waves.

The discovery will definitely provide renewed impetus to the Square Kilometre Array (SKA) Project to use the dispersion of pulsar signals, and to search for the impact of gravitational waves on signals as they travel through the universe. According to Prof Meintjes, the SKA will definitely contribute fundamentally to the Frontier research, which will provide a good deal of publicity for the UFS and South Africa, if significant contributions are made by local researchers in this field.

Video clip explaining gravitational waves

The Department of Physics will present a general, non-technical talk concerning the recent detection of gravitational waves by the 2 Laser Interferometer Gravitational Wave Observatories (LIGO):

Wednesday 24 February 2016
11:00-12:00
New lecture auditorium, Department of Physics

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept