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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Water Collection Campaign distributes 3 500 bottles in Free State
2016-02-19

 Description: KL News 2016 02 19 Water Tags: KL News 2016 02 19 Water
The Muslim Students Association (MSA), along with the Gift of the Givers Foundation, collected 3 500 5l bottles of water that was distributed to disadvantaged areas within the Free State. From left is Muhammed Bhamjee, President of MSA, Emily Thomas, project manager for Gift of the Givers Foundation, and Grace Jansen, one of the generous donors. Photo: Charl Devenish.

The Muslim Student Association (MSA) at the University of the Free State (UFS) took it upon themselves to respond to the regional water crisis being experienced in the Free State. Under the leadership of Muhammed Bhamjee, President of MSA, the association started an initiative to collect water for the purpose of distributing it to disadvantaged areas within the Free State.

The drive started out as just a humble request within the student community, but it gained a great deal of attention from staff, departments, and students from the UFS. The response was overwhelming; 3 500 5l bottles of water were donated.

Amongst the donors were the Student Affairs department and Grace Jansen, wife of Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS. Mrs Jansen said it was important for her to make a contribution: “Even though we are receiving, we need to give as well. Wherever there is a need, we need to be involved.” She believes the project has the ability to grow and gain more attention and support. She believes it needs to grow across communities to solve such problems together.

Bhamjee explains that the MSA has had a relationship with Gift of the Givers Foundation, as they have been running the campaign for quite some time. “We just felt that it’s our responsibility to get involved. Even with the little we can do, every bit counts at the end of the day.” He added that there is also a need to support fellow students at the UFS Qwaqwa Campus.

Emily Thomas, project manager for Gift of the Givers Foundation, applauds the MSA initiative, and encourages students to continue collaborating with the foundation to assist with disaster situations.

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